DISCLAIMER AND NOTE

Forward-Looking Statements

Effective as of February 2025

This website contains forward-looking statements within the meaning of the U.S. federal securities laws that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained on this website, including statements regarding the therapeutic and commercial potential and size of the estimated market opportunity of Opthea’s product in development, the viability of future opportunities, future market supply and demand, the expected timing of top-line data, the financial condition, results of operations and business of Opthea, certain plans, objectives and strategies of management of Opthea, including with respect to the current and planned clinical trials of its product candidate and the future performance of Opthea, are forward-looking statements. The words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Opthea may not actually achieve the plans, intentions or expectations disclosed in the forward-looking statements, and you should not place undue reliance on the forward-looking statements as predictions of future events. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. The forward-looking statements contained in this website reflect Opthea’s current views with respect to future events, and we assume no obligation to update any forward-looking statements except as required by applicable law.  Please refer to information, including risk factors, set forth in Opthea’s latest Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission,  and other future filings with the U.S. Securities and Exchange Commission for key factors that could cause actual results to differ materially from those projected in the forward-looking statements contained herein including risks associated with: future capital requirements and ability to continue as a going concern, the development, testing, production, marketing and sale of drug treatments, regulatory risk and potential loss of regulatory approvals, ongoing clinical studies to demonstrate sozinibercept safety, tolerability and therapeutic efficacy, additional analysis of data from Opthea’s Phase 3 clinical trials, clinical research organization and labor costs, intellectual property protections, and other factors that are of a general nature which may affect the future operating and financial performance of Opthea.

This website includes statistical and other industry and market data that we obtained from industry publications and research, surveys and studies conducted by third parties as well as our own estimates of potential market opportunities. All of the market data used in this website involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such data. Industry publications and third-party research, surveys and studies generally indicate that their information has been obtained from sources believed to be reliable, although they do not guarantee the accuracy or completeness of such information. Our estimates of the potential market opportunities for our product candidates include several key assumptions based on our industry knowledge, industry publications, third-party research and other surveys, which may be based on a small sample size and may fail to accurately reflect market opportunities. While we believe that our internal assumptions are reasonable, no independent source has verified such assumptions.

This website may contain trademarks and trade names of third parties, which are the property of their respective owners. Third party trademarks and trade names used in this website belong to the relevant owners and use is not intended to represent sponsorship, approval or association by or with any of the Opthea Group.