Focus

Opthea is committed to improving vision in patients suffering with retinal eye diseases.

We are developing a novel therapeutic called OPT-302, a VEGF-C/D ‘trap’, to be used in combination with existing standard of care anti-VEGF-A therapies.

OPT-302 has the potential to address the unmet medical need of wet AMD and DME patients, many of whom respond sub-optimally or become refractory to existing therapies for these debilitating diseases. We are advancing the clinical development of OPT-302 in wet AMD and DME clinical trials.

LEARN MORE

Disease

Wet AMD is the leading cause of blindness in the developed world in people aged over 50 years. It is caused by the abnormal growth and leakage of blood vessels at the back of the eye, which causes degeneration of the retina and vision loss.

Learn More

Technology

Opthea’s technology is centred on two members of the Vascular Endothelial Growth Factor (VEGF) family of proteins, VEGF-C and VEGF-D, and their activation of VEGF receptors.These proteins promote blood vessel development (angiogenesis) by binding and activating VEGFR-2 and VEGFR-3, and lymphatic vessel development (lymphangiogenesis), by activation of VEGFR-3.

Learn More

Opportunity

Both wet AMD and DME are associated with vascular dysfunction and fluid accumulation at the back of the eye in a region of the central retina or ‘macula’ that is needed for sharp, central vision. Vessel growth and vascular leakage are primarily driven by members of the vascular endothelial growth factor (VEGF) family, which comprises 5 members including VEGF-A, VEGF-B, VEGF-C, VEGF-D and placenta growth factor (PlGF).

Learn More

OPT-302

OPT-302, blocks two members of the vascular endothelial growth factor family, namely VEGF-C and VEGF-D, which cause blood vessels to grow and leak. Aberrant blood vessel growth and vascular leakage are hallmarks of several eye diseases including wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME).

Learn More

Clinical Trials

Opthea has completed a Phase 2b clinical trial investigating OPT-302 in wet AMD patients, and has completed a Phase 1b/2a clinical trial in patients with DME. Opthea is planning to initiate two pivotal Phase 3 clinical trials for the treatment of wet AMD in the first half of 2021.

Learn more

WITH CLINICAL TRIALS PROGRESSING
AND DATA LOOKING PROMISING,
WE BELIEVE OPT-302 WILL IMPROVE
OUTCOMES FOR PATIENTS WITH
THESE DEBILITATING DISEASES.

Opthea Researcher

Announcements

Opthea Reports Positive Phase 2a Trial Results of OPT-302 in DME

10th June 2020

Opthea has announced positive topline results of its Phase 2a trial evaluating safety and efficacy of OPT-302 administered with aflibercept in treatment refractory patients with persistent diabetic macular edema (DME).

Read More

Opthea Completes Patient Dosing in Phase 2a DME Trial

30th March 2020

Opthea has completed patient dosing and all follow-up week 12 patient visits in its Phase 2a trial of OPT-302 for treatment of diabetic macular edema (DME).

Read More

Opthea Corporate Presentation for the 2020 JPMorgan Conference

13th January 2020

Opthea to present its updated corporate presentation at the January 2020 JPMorgan conference in San Francisco.

Read More

Opthea Completes Recruitment in Phase 2a Clinical Trial of OPT-302 for Diabetic Macular Edema

7th January 2020

Opthea announces completion of patient recruiment into its Phase 2a trial evaluating the safety and efficacy of OPT-302 for the treatment of DME.

Read More

ALL ANNOUNCEMENTS