Focus

Opthea is committed to improving vision in patients suffering from retinal eye diseases.

We are developing a novel therapeutic called OPT-302, a VEGF-C/D ‘trap’, to be used in combination with existing standard of care anti-VEGF-A therapies.

OPT-302 has the potential to address the unmet medical need of wet age-related macular degeneration (AMD) and diabetic macular edema (DME) patients, many of whom respond sub-optimally or become refractory to existing therapies for these debilitating diseases. We are advancing the clinical development of OPT-302 in wet AMD and DME clinical trials.

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Disease

Wet AMD is the leading cause of blindness in the developed world in people aged over 50 years. It is caused by the abnormal growth and leakage of blood vessels at the back of the eye, which causes degeneration of the retina and vision loss.

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Technology

Opthea’s technology is centered on two members of the Vascular Endothelial Growth Factor (VEGF) family of proteins, VEGF-C and VEGF-D, and their activation of VEGF receptors. These proteins promote blood vessel development (angiogenesis) by binding and activating VEGFR-2 and VEGFR-3, and lymphatic vessel development (lymphangiogenesis), by activation of VEGFR-3.

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Opportunity

Both wet AMD and DME are associated with vascular dysfunction and fluid accumulation at the back of the eye in a region of the central retina or ‘macula’ that is needed for sharp, central vision. Vessel growth and vascular leakage are primarily driven by members of the vascular endothelial growth factor (VEGF) family, which comprises 5 members including VEGF-A, VEGF-B, VEGF-C, VEGF-D and placenta growth factor (PlGF).

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OPT-302

OPT-302, blocks two members of the vascular endothelial growth factor family, namely VEGF-C and VEGF-D, which cause blood vessels to grow and leak. Aberrant blood vessel growth and vascular leakage are hallmarks of several eye diseases including wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME).

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Clinical Trials

Opthea initiated two pivotal Phase 3 clinical trials for the treatment of wet AMD in the first half of 2021. Opthea has completed three international clinical trials investigating OPT-302 in two disease indications.  Two of the trials were in wet AMD patients including a first in human Phase 1b/2a study followed by  a large randomized controlled Phase 2bstudy, whilst the third trial was aPhase 1b/2a study in patients with DME.

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WITH CLINICAL TRIALS PROGRESSING
AND DATA LOOKING PROMISING,
WE BELIEVE OPT-302 WILL IMPROVE
OUTCOMES FOR PATIENTS WITH
THESE DEBILITATING DISEASES.

Opthea Researcher

Announcements

Opthea to Present at the Jefferies 2023 Healthcare Conference

26 May 2023

Dr. Megan Baldwin, the Company’s Chief Executive Officer will present at the Jefferies Healthcare Conference on June 7-9, 2023.

Webcast Registration

Opthea to Present at SVB Securities Global Biopharma Conference 2023

7 February 2023

Opthea will present at SVB Securities Global Biopharma Conference on February 2, 2023, at 10:00 AM EST.

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Opthea To Present at Sequire Biotechnology Conference

31 January 2023

Opthea Limited announced today that Dr. Megan Baldwin, the Company’s Chief Executive Officer will present at the Sequire Biotechnology Conference being held virtually on February 2, 2023.

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Opthea Corporate Presentation – San Francisco Jan 2023

11 January 2023

Leading Therapeutic Innovation in Retinal Diseases

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ALL ANNOUNCEMENTS

Investigating Anti-VEGF-C and -D Therapy in WetAMD